TLL1 Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 4q32.3
Cellular Component:  extracellular region
Molecular Function:  calcium ion binding; metalloendopeptidase activity; zinc ion binding
Biological Process:  cell differentiation; extracellular matrix disassembly; proteolysis; skeletal system development
Disease: Atrial Septal Defect 6
Reference #:  O43897 (UniProtKB)
Alt. Names/Synonyms: ASD6; TLL; TLL1; tolloid like 1; tolloid-like 1; Tolloid-like protein 1
Gene Symbols: TLL1
Molecular weight: 114,709 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene