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TLL1
Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 4q32.3 |
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Cellular Component:
extracellular region
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Molecular Function:
calcium ion binding; metalloendopeptidase activity; zinc ion binding
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Biological Process:
cell differentiation; extracellular matrix disassembly; proteolysis; skeletal system development
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Disease: Atrial Septal Defect 6
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Reference #:
O43897
(UniProtKB)
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Alt. Names/Synonyms: ASD6; TLL; TLL1; tolloid like 1; tolloid-like 1; Tolloid-like protein 1
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Gene Symbols: TLL1
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Molecular weight:
114,709 Da
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Basal Isoelectric point:
5.69
Predict pI for various phosphorylation states
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