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TSSK1
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Testis-specific. Present in sperm (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); TSSK family |
| Chromosomal Location of Human Ortholog: 16 A3|16 11.09 cM |
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Cellular Component:
acrosomal vesicle; cell projection; cilium; cytoplasm; cytoplasmic vesicle; motile cilium; nucleus
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Molecular Function:
ATP binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transferase activity
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Biological Process:
cell differentiation; intracellular signal transduction; multicellular organism development; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation; spermatid development; spermatogenesis
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Reference #:
Q61241
(UniProtKB)
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Alt. Names/Synonyms: serine/threonine kinase 22A (spermiogenesis associated); Serine/threonine-protein kinase 22A; Stk2; Stk22a; Testis-specific kinase 1; testis-specific serine kinase 1; testis-specific serine/threonine kinase; Testis-specific serine/threonine-protein kinase 1; Tsk; TSK-; TSK-1; Tsk1; Tssk; TSSK-1; Tssk1; Tssk1b
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Gene Symbols: Tssk1b
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Molecular weight:
41,589 Da
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Basal Isoelectric point:
7.61
Predict pI for various phosphorylation states
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