TPX2 Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. Belongs to the TPX2 family. Expressed in lung carcinoma cell lines but not in normal lung tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Microtubule-binding
Chromosomal Location of mouse Ortholog: 2|2 H1
Cellular Component:  aster; axon hillock; cytoplasm; cytoskeleton; intercellular bridge; microtubule; microtubule cytoskeleton; mitotic spindle; nucleoplasm; nucleus; spindle; spindle pole
Molecular Function:  importin-alpha family protein binding; protein binding; protein kinase binding
Biological Process:  activation of protein kinase activity; apoptotic process; cell cycle; cell division; microtubule nucleation; mitotic spindle assembly; negative regulation of microtubule depolymerization; regulation of mitotic spindle organization; spindle assembly
Reference #:  A2APB8 (UniProtKB)
Alt. Names/Synonyms: 2610005B21Rik; DIL2; OTTMUSP00000016903; OTTMUSP00000016904; p10; p100; REP; REPP86; Targeting protein for Xklp2; Tpx2; TPX2, microtubule-associated; TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated protein homolog (Xenopus laevis)
Gene Symbols: Tpx2
Molecular weight: 85,894 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein