AKAP9 Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery. Isoform 4: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Widely expressed (PubMed:10202149). Isoform 4: Highly expressed in skeletal muscle and in pancreas (PubMed:9482789). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5|5 A1
Cellular Component:  centrosome; ciliary basal body; cis-Golgi network; cytoplasm; cytoskeleton; dendritic branch; extrinsic component of postsynaptic density membrane; Golgi apparatus; Golgi stack; neuronal cell body; pericentriolar material; synaptic membrane
Molecular Function:  potassium channel regulator activity; protein binding; protein kinase A regulatory subunit binding
Biological Process:  maintenance of centrosome location; negative regulation of adenylate cyclase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of potassium ion transmembrane transporter activity; regulation of Golgi organization; regulation of ventricular cardiac muscle cell membrane repolarization; Sertoli cell development; signal transduction; spermatogenesis
Reference #:  Q70FJ1 (UniProtKB)
Alt. Names/Synonyms: 5730481H23Rik; A kinase (PRKA) anchor protein (yotiao) 9; A-kinase anchor protein 9; AKAP; AKAP-9; AKAP450; Akap9; AW545847; C79026; G1-448-15; Kiaa0803; mei2-; mei2-5; mKIAA0803; OTTMUSP00000017425; PRKA9; Protein kinase A-anchoring protein 9; rep; repro12
Gene Symbols: Akap9
Molecular weight: 436,229 Da
Basal Isoelectric point: 4.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene