MT1 Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. Belongs to the metallothionein superfamily. Type 1 family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 8 C5|8 46.34 cM
Cellular Component:  cytoplasm; cytosol; lysosome; nucleus
Molecular Function:  copper ion binding; metal ion binding; zinc ion binding
Biological Process:  cellular metal ion homeostasis; cellular response to cadmium ion; cellular response to chromate; cellular response to copper ion; cellular response to zinc ion; cellular zinc ion homeostasis; detoxification of copper ion; negative regulation of neuron apoptotic process; nitric oxide mediated signal transduction
Reference #:  P02802 (UniProtKB)
Alt. Names/Synonyms: metallothionein 1; Metallothionein-1; Metallothionein-I; MT-1; MT-I; Mt1
Gene Symbols: Mt1
Molecular weight: 6,018 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
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MT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene