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CYP11B2
Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.14.15.4; EC 1.14.15.5; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 8q24.3 |
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Cellular Component:
mitochondrial inner membrane; mitochondrion
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Molecular Function:
corticosterone 18-monooxygenase activity; heme binding; iron ion binding; steroid 11-beta-monooxygenase activity; steroid hydroxylase activity
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Biological Process:
aldosterone biosynthetic process; C21-steroid hormone biosynthetic process; cellular response to hormone stimulus; cellular response to peptide hormone stimulus; cellular response to potassium ion; cholesterol metabolic process; cortisol biosynthetic process; cortisol metabolic process; glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; potassium ion homeostasis; regulation of blood volume by renal aldosterone; renal water homeostasis; sodium ion homeostasis; sterol metabolic process
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Disease: Corticosterone Methyloxidase Type I Deficiency; Corticosterone Methyloxidase Type Ii Deficiency
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Reference #:
P19099
(UniProtKB)
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Alt. Names/Synonyms: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; C11B2; Corticosterone 18-monooxygenase, CYP11B2; CPN2; CYP11B; CYP11B2; CYP11BL; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2, mitochondrial; cytochrome P450 family 11 subfamily B member 2; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P-450C18; P450aldo; P450C18; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
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Gene Symbols: CYP11B2
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Molecular weight:
57,560 Da
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Basal Isoelectric point:
9.47
Predict pI for various phosphorylation states
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