CYP11B2 Preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 8q24.3
Cellular Component:  mitochondrial inner membrane; mitochondrion
Molecular Function:  corticosterone 18-monooxygenase activity; heme binding; iron ion binding; steroid 11-beta-monooxygenase activity; steroid hydroxylase activity
Biological Process:  aldosterone biosynthetic process; C21-steroid hormone biosynthetic process; cellular response to hormone stimulus; cellular response to peptide hormone stimulus; cellular response to potassium ion; cholesterol metabolic process; cortisol biosynthetic process; cortisol metabolic process; glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; potassium ion homeostasis; regulation of blood volume by renal aldosterone; renal water homeostasis; sodium ion homeostasis; sterol metabolic process
Disease: Corticosterone Methyloxidase Type I Deficiency; Corticosterone Methyloxidase Type Ii Deficiency
Reference #:  P19099 (UniProtKB)
Alt. Names/Synonyms: ALDOS; Aldosterone synthase; Aldosterone-synthesizing enzyme; C11B2; Corticosterone 18-monooxygenase, CYP11B2; CPN2; CYP11B; CYP11B2; CYP11BL; CYPXIB2; Cytochrome P-450Aldo; Cytochrome P-450C18; Cytochrome P450 11B2, mitochondrial; cytochrome P450 family 11 subfamily B member 2; cytochrome P450, family 11, subfamily B, polypeptide 2; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2; mitochondrial cytochrome P450, family 11, subfamily B, polypeptide 2; P-450C18; P450aldo; P450C18; Steroid 11-beta-hydroxylase, CYP11B2; steroid 11-beta-monooxygenase; steroid 11-beta/18-hydroxylase; Steroid 18-hydroxylase; steroid 18-hydroxylase, aldosterone synthase, P450C18, P450aldo
Gene Symbols: CYP11B2
Molecular weight: 57,560 Da
Basal Isoelectric point: 9.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene