NUEM Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFA9 subunit family. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 12p13.32
Cellular Component:  mitochondrial matrix; mitochondrial membrane; mitochondrial respiratory chain complex I; mitochondrion; nucleoplasm
Molecular Function:  coenzyme binding; NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; protein binding; protein-containing complex binding
Biological Process:  circadian rhythm; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; response to glucose; sodium ion transport
Disease: Mitochondrial Complex I Deficiency, Nuclear Type 26
Reference #:  Q16795 (UniProtKB)
Alt. Names/Synonyms: CI-39kD; Complex I-39kD; MGC111043; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 2-like (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; NADH-ubiquinone oxidoreductase 39 kDa subunit; NDUA9; NDUFA9; NDUFS2L; NUEM; SDR22E1; short chain dehydrogenase/reductase family 22E, member 1
Gene Symbols: NDUFA9
Molecular weight: 42,510 Da
Basal Isoelectric point: 9.81  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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