PRDX5 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Belongs to the peroxiredoxin family. Prx5 subfamily. Widely expressed. 4 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; intracellular membrane-bounded organelle; mitochondrial matrix; mitochondrion; nucleus; perinuclear region of cytoplasm; peroxisomal matrix; peroxisome
Molecular Function:  cysteine-type endopeptidase inhibitor activity involved in apoptotic process; peroxidase activity; protein binding; protein dimerization activity; RNA polymerase III regulatory region DNA binding; signaling receptor binding; thioredoxin peroxidase activity
Biological Process:  apoptotic process; cellular oxidant detoxification; cellular response to oxidative stress; cellular response to reactive oxygen species; inflammatory response; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of transcription by RNA polymerase III; oxidation-reduction process; response to oxidative stress
Reference #:  P30044 (UniProtKB)
Alt. Names/Synonyms: ACR1; Alu co-repressor 1; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; B166; epididymis secretory protein Li 55; HEL-S-55; Liver tissue 2D-page spot 71B; MGC117264; MGC142283; MGC142285; peroxiredoxin 5; Peroxiredoxin V; Peroxiredoxin-5, mitochondrial; Peroxisomal antioxidant enzyme; PLP; PMP20; PRDX5; PRDX6; Prx-V; PRXV; SBBI10; Thioredoxin peroxidase PMP20; Thioredoxin reductase; Thioredoxin-dependent peroxiredoxin 5; TPx type VI
Gene Symbols: PRDX5
Molecular weight: 22,086 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein