P70S6KB Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; Translation; p70 subfamily
Chromosomal Location of human Ortholog: 11q13.2
Cellular Component:  nucleoplasm
Molecular Function:  ATP binding; peptide binding; protein kinase activity
Biological Process:  positive regulation of translational initiation; protein kinase B signaling; signal transduction; TOR signaling; translation
Reference #:  Q9UBS0 (UniProtKB)
Alt. Names/Synonyms: 70 kDa ribosomal protein S6 kinase 2; KLS; KS6B2; p70 ribosomal S6 kinase beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; p70(S6K)-beta; p70-beta; P70-beta-1; P70-beta-2; p70-S6K 2; P70S6K2; p70S6Kb; ribosomal protein S6 kinase B2; Ribosomal protein S6 kinase beta-2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; RPS6KB2; S6 kinase-related kinase; S6K-beta; S6K-beta-2; S6K-beta2; S6K2; S6KB; S6Kbeta; S6KI(2); serine/threonine-protein kinase 14 beta; Serine/threonine-protein kinase 14B; SRK; STK14B
Gene Symbols: RPS6KB2
Molecular weight: 53,455 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene