FECH Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 4.99.1.1; Lyase; Mitochondrial

Chromosomal Location of human Ortholog: 18q21.31

Cellular Component: mitochondrial inner membrane; mitochondrial matrix; mitochondrion

Molecular Function: 2 iron, 2 sulfur cluster binding; ferrochelatase activity; ferrous iron binding; heme binding; iron-responsive element binding; protein binding; protein homodimerization activity

Biological Process: cellular response to dexamethasone stimulus; cholesterol metabolic process; detection of UV; erythrocyte differentiation; generation of precursor metabolites and energy; heme biosynthetic process; multicellular organismal-level iron ion homeostasis; protoporphyrinogen IX metabolic process; regulation of eIF2 alpha phosphorylation by heme; regulation of hemoglobin biosynthetic process; response to arsenic-containing substance; response to ethanol; response to insecticide; response to lead ion; response to light stimulus; response to methylmercury; response to platinum ion; response to xenobiotic stimulus; very-low-density lipoprotein particle assembly

Disease: Protoporphyria, Erythropoietic

Reference #: P22830 (UniProtKB)

Alt. Names/Synonyms: EPP; EPP1; FCE; FECH; ferrochelatase; ferrochelatase (protoporphyria); Ferrochelatase, mitochondrial; Heme synthase; heme synthetase; HEMH; Protoheme ferro-lyase; protoporphyria

Gene Symbols: FECH

Molecular weight: 47,862 Da

Basal Isoelectric point: 8.96 Predict pI for various phosphorylation states

Select Structure to View Below
FECH

Get PyMOL Script Get Chimera Script