FECH Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 4.99.1.1; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 18q21.31
Cellular Component:  mitochondrial inner membrane; mitochondrial matrix
Molecular Function:  2 iron, 2 sulfur cluster binding; ferrochelatase activity; ferrous iron binding; protein binding
Biological Process:  generation of precursor metabolites and energy; heme biosynthetic process; protoporphyrinogen IX metabolic process; response to light stimulus
Disease: Protoporphyria, Erythropoietic
Reference #:  P22830 (UniProtKB)
Alt. Names/Synonyms: EPP; FCE; FECH; ferrochelatase; ferrochelatase (protoporphyria); Ferrochelatase, mitochondrial; Heme synthase; heme synthetase; HEMH; Protoheme ferro-lyase
Gene Symbols: FECH
Molecular weight: 47,862 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Select Structure to View Below

FECH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein