FECH Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 18q21.31
Cellular Component:  mitochondrial inner membrane; mitochondrial matrix
Molecular Function:  2 iron, 2 sulfur cluster binding; ferrochelatase activity; ferrous iron binding; protein binding
Biological Process:  generation of precursor metabolites and energy; heme biosynthetic process; protoporphyrinogen IX metabolic process; response to light stimulus
Disease: Protoporphyria, Erythropoietic
Reference #:  P22830 (UniProtKB)
Alt. Names/Synonyms: EPP; FCE; FECH; ferrochelatase; ferrochelatase (protoporphyria); Ferrochelatase, mitochondrial; Heme synthase; heme synthetase; HEMH; Protoheme ferro-lyase
Gene Symbols: FECH
Molecular weight: 47,862 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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