FECH Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 18 E1|18 37.43 cM
Cellular Component:  membrane; mitochondrial inner membrane; mitochondrion
Molecular Function:  2 iron, 2 sulfur cluster binding; ferrochelatase activity; heme binding; iron ion binding; iron-responsive element binding; iron-sulfur cluster binding; lyase activity; metal ion binding; protein binding; tetrapyrrole binding
Biological Process:  cholesterol metabolic process; detection of UV; erythrocyte differentiation; heme biosynthetic process; iron ion homeostasis; porphyrin-containing compound biosynthetic process; protoporphyrinogen IX metabolic process; regulation of eIF2 alpha phosphorylation by heme; regulation of gene expression; regulation of hemoglobin biosynthetic process; response to light stimulus; very-low-density lipoprotein particle assembly
Reference #:  P22315 (UniProtKB)
Alt. Names/Synonyms: AI894116; fch; Fcl; Fech; ferrochelatase; Ferrochelatase, mitochondrial; Heme synthase; heme synthetase; HEMH; Protoheme ferro-lyase
Gene Symbols: Fech
Molecular weight: 47,130 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene