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GGT5
Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). Belongs to the gamma-glutamyltransferase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.3.2.2; EC 3.4.19.13; EC 3.4.19.14; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Other Amino Acids Metabolism - cyanoamino acid; Other Amino Acids Metabolism - glutathione; Other Amino Acids Metabolism - selenoamino acid; Other Amino Acids Metabolism - taurine and hypotaurine; Transferase |
| Chromosomal Location of Human Ortholog: 22q11.23 |
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Cellular Component:
integral component of membrane; intrinsic component of plasma membrane; plasma membrane
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Molecular Function:
glutathione hydrolase activity; hypoglycin A gamma-glutamyl transpeptidase activity; leukotriene C4 gamma-glutamyl transferase activity; leukotriene-C(4) hydrolase; peptidyltransferase activity
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Biological Process:
cellular amino acid metabolic process; fatty acid metabolic process; glutathione biosynthetic process; glutathione catabolic process; leukotriene D4 biosynthetic process; leukotriene metabolic process; proteolysis; translation
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Reference #:
P36269
(UniProtKB)
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Alt. Names/Synonyms: DKFZp566O011; FLJ92733; gamma-glutamyl cleaving enzyme; Gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyl transpeptidase-related protein; Gamma-glutamyltransferase 5; Gamma-glutamyltransferase 5 heavy chain; Gamma-glutamyltransferase 5 light chain; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; GGL; GGT 5; GGT-rel; GGT5; GGTLA1; Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain; Glutathione hydrolase 5 proenzyme; Leukotriene-C4 hydrolase
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Gene Symbols: GGT5
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Molecular weight:
62,261 Da
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Basal Isoelectric point:
7.24
Predict pI for various phosphorylation states
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