GGT5 Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). Belongs to the gamma-glutamyltransferase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; EC; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Other Amino Acids Metabolism - cyanoamino acid; Other Amino Acids Metabolism - glutathione; Other Amino Acids Metabolism - selenoamino acid; Other Amino Acids Metabolism - taurine and hypotaurine; Transferase
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component:  integral component of membrane; intrinsic component of plasma membrane; plasma membrane
Molecular Function:  glutathione hydrolase activity; hypoglycin A gamma-glutamyl transpeptidase activity; leukotriene C4 gamma-glutamyl transferase activity; leukotriene-C(4) hydrolase; peptidyltransferase activity
Biological Process:  cellular amino acid metabolic process; fatty acid metabolic process; glutathione biosynthetic process; glutathione catabolic process; leukotriene D4 biosynthetic process; leukotriene metabolic process; proteolysis; translation
Reference #:  P36269 (UniProtKB)
Alt. Names/Synonyms: DKFZp566O011; FLJ92733; gamma-glutamyl cleaving enzyme; Gamma-glutamyl transpeptidase-related enzyme; gamma-glutamyl transpeptidase-related protein; Gamma-glutamyltransferase 5; Gamma-glutamyltransferase 5 heavy chain; Gamma-glutamyltransferase 5 light chain; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; GGL; GGT 5; GGT-rel; GGT5; GGTLA1; Glutathione hydrolase 5 heavy chain; Glutathione hydrolase 5 light chain; Glutathione hydrolase 5 proenzyme; Leukotriene-C4 hydrolase
Gene Symbols: GGT5
Molecular weight: 62,261 Da
Basal Isoelectric point: 7.24  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein