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ROMO1
Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage. Belongs to the MGR2 family. Up-regulated in a number of cancer cell lines when compared to a normal lung fibroblast cell line. Highly expressed in brain tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Membrane protein, integral; Mitochondrial |
| Chromosomal Location of human Ortholog: 20q11.22 |
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Cellular Component:
mitochondrion; TIM23 mitochondrial import inner membrane translocase complex
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Molecular Function:
protein binding
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Biological Process:
antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to reactive oxygen species; cytolysis by host of symbiont cells; defense response to bacterium; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; intracellular protein transport; killing of cells of another organism; positive regulation of cell population proliferation; positive regulation of reactive oxygen species metabolic process; protein import into mitochondrial matrix; protein insertion into mitochondrial inner membrane; replicative senescence
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Reference #:
P60602
(UniProtKB)
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Alt. Names/Synonyms: bA353C18.2; C20orf52; Epididymis tissue protein Li 175; Glyrichin; MGC111180; Mitochondrial targeting GxxxG motif protein; mitochondrial targeting GXXXG protein; MTGM; MTGMP; PCM19; Protein MGR2 homolog; Reactive oxygen species modulator 1; ROMO1; ROS modulator 1
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Gene Symbols: ROMO1
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Molecular weight:
8,183 Da
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Basal Isoelectric point:
9.58
Predict pI for various phosphorylation states
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