CACNG7 Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. Detected in heart left ventricle (PubMed:21127204). Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 7 A1|7 1.95 cM
Cellular Component:  AMPA glutamate receptor complex; cerebellar mossy fiber; cytoplasm; early endosome; glutamatergic synapse; integral component of membrane; integral component of postsynaptic density membrane; L-type voltage-gated calcium channel complex; membrane; neuron projection; neuronal cell body; plasma membrane; postsynaptic density membrane
Molecular Function:  calcium channel activity; calcium channel regulator activity; channel regulator activity; voltage-gated calcium channel activity; voltage-gated ion channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; ion transport; neurotransmitter receptor internalization; neurotransmitter receptor localization to postsynaptic specialization membrane; neurotransmitter receptor transport, postsynaptic endosome to lysosome; positive regulation of dendrite extension; positive regulation of synaptic transmission, glutamatergic; postsynaptic neurotransmitter receptor diffusion trapping; regulation of AMPA receptor activity; regulation of ion transmembrane transport; regulation of mRNA stability; transmission of nerve impulse
Reference #:  P62956 (UniProtKB)
Alt. Names/Synonyms: Cacng7; calcium channel, voltage-dependent, gamma subunit 7; neuronal voltage-gated calcium channel gamma-7 subunit; voltage dependent calcium channel gamma 7 subunit; Voltage-dependent calcium channel gamma-7 subunit
Gene Symbols: Cacng7
Molecular weight: 31,003 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene