TOP2B Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Belongs to the type II topoisomerase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; EC; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase
Chromosomal Location of Human Ortholog: 14|14 A2
Cellular Component:  cytosol; nucleolus; nucleoplasm; nucleus; viral integration complex
Molecular Function:  ATP binding; chromatin binding; DNA binding; DNA topoisomerase activity; DNA topoisomerase type II (ATP-hydrolyzing) activity; enzyme binding; histone deacetylase binding; isomerase activity; metal ion binding; nucleotide binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase C binding; ribonucleoprotein complex binding
Biological Process:  axonogenesis; cell aging; cellular response to ATP; cellular response to hydrogen peroxide; DNA metabolic process; DNA topological change; forebrain development; mitotic DNA integrity checkpoint; neuron migration; positive regulation of double-strand break repair via nonhomologous end joining; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate; resolution of meiotic recombination intermediates; sister chromatid segregation
Reference #:  Q64511 (UniProtKB)
Alt. Names/Synonyms: D230016L12Rik; DNA topoisomerase 2-beta; DNA topoisomerase II, beta isozyme; Top-2; Top2b; topoisomerase (DNA) II beta
Gene Symbols: Top2b
Molecular weight: 181,909 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene