CORIN Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared to isoform 1. Belongs to the peptidase S1 family. Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell surface; EC 3.4.21.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 5|5 C3.2
Cellular Component:  actin cytoskeleton; cell surface; cytoplasmic vesicle; extracellular region; integral component of membrane; integral component of plasma membrane; membrane; nuclear body; plasma membrane
Molecular Function:  hydrolase activity; peptidase activity; scavenger receptor activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  female pregnancy; neuron differentiation; peptide hormone processing; proteolysis; regulation of blood pressure; regulation of renal sodium excretion; regulation of systemic arterial blood pressure by atrial natriuretic peptide
Reference #:  Q9Z319 (UniProtKB)
Alt. Names/Synonyms: Atrial natriuretic peptide-converting enzyme; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; AV273130; Corin; corin, serine peptidase; Crn; Low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; Lrp4; MGC118735; Pro-ANP-converting enzyme
Gene Symbols: Corin
Molecular weight: 123,006 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
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CORIN

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene