CORIN Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface; EC 3.4.21.-; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 5|5 C3.2
Cellular Component:  actin cytoskeleton; cell surface; cytoplasmic vesicle; extracellular region; integral component of membrane; integral component of plasma membrane; membrane; nuclear body; plasma membrane
Molecular Function:  hydrolase activity; peptidase activity; scavenger receptor activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  female pregnancy; neuron differentiation; peptide hormone processing; proteolysis; regulation of blood pressure; regulation of renal sodium excretion; regulation of systemic arterial blood pressure by atrial natriuretic peptide
Reference #:  Q9Z319 (UniProtKB)
Alt. Names/Synonyms: Atrial natriuretic peptide-converting enzyme; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; AV273130; Corin; Crn; Low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; Lrp4; MGC118735; Pro-ANP-converting enzyme
Gene Symbols: Corin
Molecular weight: 123,006 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene