prothrombin Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Belongs to the peptidase S1 family. Expressed by the liver and secreted in plasma. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component:  endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane
Molecular Function:  calcium ion binding; enzyme activator activity; growth factor activity; heparin binding; lipopolysaccharide binding; protein binding; serine-type endopeptidase activity; signaling receptor binding; thrombospondin receptor activity
Biological Process:  acute-phase response; antimicrobial humoral immune response mediated by antimicrobial peptide; blood coagulation; blood coagulation, intrinsic pathway; cell surface receptor signaling pathway; cellular protein metabolic process; cytolysis by host of symbiont cells; ER to Golgi vesicle-mediated transport; fibrinolysis; G protein-coupled receptor signaling pathway; leukocyte migration; multicellular organism development; negative regulation of astrocyte differentiation; negative regulation of cytokine production involved in inflammatory response; negative regulation of fibrinolysis; negative regulation of platelet activation; negative regulation of proteolysis; neutrophil mediated killing of gram-negative bacterium; platelet activation; positive regulation of blood coagulation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of collagen biosynthetic process; positive regulation of JAK-STAT cascade; positive regulation of lipid kinase activity; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of protein localization to nucleus; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species metabolic process; positive regulation of release of sequestered calcium ion into cytosol; proteolysis; regulation of blood coagulation; regulation of cell shape; regulation of complement activation; regulation of cytosolic calcium ion concentration; regulation of gene expression; regulation of signaling receptor activity; response to wounding
Disease: Pregnancy Loss, Recurrent, Susceptibility To, 2; Prothrombin Deficiency, Congenital; Stroke, Ischemic; Thrombophilia Due To Thrombin Defect
Reference #:  P00734 (UniProtKB)
Alt. Names/Synonyms: Activation peptide fragment 1; Activation peptide fragment 2; Coagulation factor II; coagulation factor II (thrombin); coagulation factor II, thrombin; F2; prepro-coagulation factor II; Prothrombin; prothrombin B-chain; PT; RPRGL2; THPH1; THRB; thrombin factor II; Thrombin heavy chain; Thrombin light chain
Gene Symbols: F2
Molecular weight: 70,037 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.