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COL11A1
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. Belongs to the fibrillar collagen family. Cartilage, placenta and some tumor or virally transformed cell lines. Isoforms using exon IIA or IIB are found in the cartilage while isoforms using only exon IIB are found in the tendon. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Extracellular matrix; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 1p21.1 |
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Cellular Component:
collagen type XI trimer; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular region; extracellular space
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Molecular Function:
extracellular matrix binding; extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; heparan sulfate binding; heparin binding; metal ion binding; protein-macromolecule adaptor activity
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Biological Process:
cartilage condensation; chondrocyte development; collagen fibril organization; detection of mechanical stimulus involved in sensory perception of sound; embryonic skeletal system morphogenesis; endodermal cell differentiation; extracellular matrix organization; inner ear morphogenesis; ossification; proteoglycan metabolic process; sensory perception of sound; tendon development; ventricular cardiac muscle tissue morphogenesis; visual perception
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Disease: Deafness, Autosomal Dominant 37; Fibrochondrogenesis 1; Intervertebral Disc Disease; Marshall Syndrome; Stickler Syndrome, Type Ii
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Reference #:
P12107
(UniProtKB)
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Alt. Names/Synonyms: CO11A1; COBA1; COL11A1; COLL6; Collagen alpha-1(XI) chain; collagen type XI alpha 1 chain; collagen XI, alpha-1 polypeptide; collagen, type XI, alpha 1; deafness, autosomal dominant 37; DFNA37; STL2
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Gene Symbols: COL11A1
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Molecular weight:
181,065 Da
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Basal Isoelectric point:
5.06
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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