CAPN10 Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. Belongs to the peptidase C2 family. Detected in primary skeletal muscle cells (at protein level). Ubiquitous. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 3.4.22.-; Mitochondrial; Protease
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  cytosol; mitochondrion; plasma membrane
Molecular Function:  calcium-dependent cysteine-type endopeptidase activity; cytoskeletal protein binding; SNARE binding
Biological Process:  actin cytoskeleton reorganization; cellular component disassembly involved in execution phase of apoptosis; cellular response to insulin stimulus; positive regulation of glucose import; positive regulation of insulin secretion; positive regulation of intracellular transport; positive regulation of type B pancreatic cell apoptotic process; proteolysis; type B pancreatic cell apoptotic process
Disease: Diabetes Mellitus, Noninsulin-dependent, 1
Reference #:  Q9HC96 (UniProtKB)
Alt. Names/Synonyms: calcium-activated neutral protease; Calcium-activated neutral proteinase 10; calpain 10; Calpain-10; calpain-like protease CAPN10; CAN10; CANP 10; CANP10; CAPN10; KIAA1845; NIDDM1
Gene Symbols: CAPN10
Molecular weight: 74,952 Da
Basal Isoelectric point: 7.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein