IRAK2 Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Note: This description may include information from UniProtKB.
Protein type: IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component:  cytosol; endosome membrane; plasma membrane
Molecular Function:  ATP binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  activation of MAPK activity; I-kappaB kinase/NF-kappaB signaling; inflammatory response; interleukin-1-mediated signaling pathway; JNK cascade; lipopolysaccharide-mediated signaling pathway; MyD88-dependent toll-like receptor signaling pathway; negative regulation of NF-kappaB transcription factor activity; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of NF-kappaB transcription factor activity; protein phosphorylation; regulation of cytokine-mediated signaling pathway; response to interleukin-1; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway
Reference #:  O43187 (UniProtKB)
Alt. Names/Synonyms: interleukin-1 receptor associated kinase-2; interleukin-1 receptor-associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; IRAK2; MGC150550
Gene Symbols: IRAK2
Molecular weight: 69,433 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB