CAPN10 Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. Belongs to the peptidase C2 family. Detected in primary skeletal muscle cells (at protein level). Ubiquitous. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 3.4.22.-; Mitochondrial; Protease
Chromosomal Location of Human Ortholog: 1|1 D
Cellular Component:  cell cortex; cytoplasm; cytoskeleton; cytosol; intracellular membrane-bounded organelle; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleus; plasma membrane
Molecular Function:  calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytoskeletal protein binding; hydrolase activity; peptidase activity; SNARE binding
Biological Process:  actin cytoskeleton reorganization; aging; autophagy of mitochondrion; cellular response to insulin stimulus; mitochondrion organization; positive regulation of apoptotic process; positive regulation of glucose import; positive regulation of insulin secretion; positive regulation of intracellular transport; positive regulation of type B pancreatic cell apoptotic process; proteolysis; response to nutrient levels; type B pancreatic cell apoptotic process
Reference #:  Q9ESK3 (UniProtKB)
Alt. Names/Synonyms: AW049679; Calcium-activated neutral proteinase 10; calpain 10; calpain 8; Calpain-10; CAN10; CANP 10; Capn10; Capn8; mKIAA1845
Gene Symbols: Capn10
Molecular weight: 74,596 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene