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CAPN10
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. Belongs to the peptidase C2 family. Detected in primary skeletal muscle cells (at protein level). Ubiquitous. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; EC 3.4.22.-; Mitochondrial; Protease |
| Chromosomal Location of mouse Ortholog: 1|1 D |
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Cellular Component:
cell cortex; cytoplasm; cytosol; mitochondrial inner membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; plasma membrane
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Molecular Function:
calcium-dependent cysteine-type endopeptidase activity; cysteine-type peptidase activity; cytoskeletal protein binding; hydrolase activity; peptidase activity; SNARE binding
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Biological Process:
actin cytoskeleton organization; autophagy of mitochondrion; cellular response to insulin stimulus; mitochondrion organization; positive regulation of apoptotic process; positive regulation of glucose import; positive regulation of insulin secretion; positive regulation of intracellular transport; positive regulation of type B pancreatic cell apoptotic process; protein catabolic process; proteolysis; regulation of actin cytoskeleton organization; response to nutrient levels; type B pancreatic cell apoptotic process
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Reference #:
Q9ESK3
(UniProtKB)
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Alt. Names/Synonyms: AW049679; Calcium-activated neutral proteinase 10; calpain 10; calpain 8; Calpain-10; CAN10; CANP 10; Capn10; Capn8; mKIAA1845
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Gene Symbols: Capn10
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Molecular weight:
74,596 Da
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Basal Isoelectric point:
7
Predict pI for various phosphorylation states
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