PDE7B Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. Highly expressed in brain. Also expressed in heart, liver, skeletal muscle and pancreas. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 6q23.3
Cellular Component:  cytosol
Molecular Function:  metal ion binding
Biological Process:  cAMP catabolic process; chemical synaptic transmission; G protein-coupled receptor signaling pathway; signal transduction
Reference #:  Q9NP56 (UniProtKB)
Alt. Names/Synonyms: bA472E5.1; cAMP-specific 3',5'-cyclic phosphodiesterase 7B; high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase; MGC88256; PDE7B; phosphodiesterase 7B; rolipram-insensitive phosphodiesterase type 7
Gene Symbols: PDE7B
Molecular weight: 51,835 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
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PDE7B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene