LGR8 Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). Belongs to the G-protein coupled receptor 1 family. Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 13q13.1
Cellular Component:  plasma membrane
Molecular Function:  peptide hormone binding; protein-hormone receptor activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; male gonad development; negative regulation of apoptotic process; negative regulation of cell proliferation; oocyte maturation; positive regulation of cAMP-mediated signaling
Disease: Cryptorchidism, Unilateral Or Bilateral
Reference #:  Q8WXD0 (UniProtKB)
Alt. Names/Synonyms: G protein coupled receptor affecting testicular descent; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; GPR106; GREAT; INSL3R; leucine-rich repeat-containing G protein-coupled receptor 8; Leucine-rich repeat-containing G-protein coupled receptor 8; LGR8; LGR8.1; Relaxin family peptide receptor 2; Relaxin receptor 2; relaxin/insulin like family peptide receptor 2; relaxin/insulin-like family peptide receptor 2; RXFP2; RXFPR2
Gene Symbols: RXFP2
Molecular weight: 86,453 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB