GDAP1 Regulates the mitochondrial network by promoting mitochondrial fission. Belongs to the GST superfamily. Highly expressed in whole brain and spinal cord. Predominant expression in central tissues of the nervous system not only in neurons but also in Schwann cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q21.11
Cellular Component:  cytosol; integral component of mitochondrial outer membrane; mitochondrion
Biological Process:  cellular response to vitamin D; mitochondrial fission; mitochondrial fusion; protein targeting to mitochondrion; response to retinoic acid
Disease: Charcot-marie-tooth Disease, Axonal, Type 2k; Charcot-marie-tooth Disease, Axonal, With Vocal Cord Paresis, Autosomal Recessive; Charcot-marie-tooth Disease, Recessive Intermediate A; Charcot-marie-tooth Disease, Type 4a
Reference #:  Q8TB36 (UniProtKB)
Alt. Names/Synonyms: Charcot-Marie-Tooth neuropathy 4A; CMT4; CMT4A; CMTRIA; ganglioside induced differentiation associated protein 1; Ganglioside-induced differentiation-associated protein 1; GDAP1
Gene Symbols: GDAP1
Molecular weight: 41,346 Da
Basal Isoelectric point: 8.48  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene