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TSSK1
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Testis-specific. Present in sperm (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); TSSK family |
| Chromosomal Location of human Ortholog: 5q22.2 |
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Cellular Component:
acrosomal vesicle; motile cilium; nucleotide-activated protein kinase complex
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Molecular Function:
ATP binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding
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Biological Process:
cellular response to glucose starvation; intracellular signal transduction; negative regulation of TOR signaling; peptidyl-serine phosphorylation; protein phosphorylation; spermatid development
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Reference #:
Q9BXA7
(UniProtKB)
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Alt. Names/Synonyms: FKSG81; OTTHUMP00000159055; serine/threonine kinase 22D (spermiogenesis associated); serine/threonine kinase FKSG81; Serine/threonine-protein kinase 22A; spermiogenesis associated 4; SPOGA1; SPOGA4; STK22A; STK22D; testis specific serine kinase 1B; testis tissue sperm-binding protein Li 55e; Testis-specific kinase 1; testis-specific serine kinase 1; Testis-specific serine/threonine-protein kinase 1; TSK-1; TSK1; TSSK-1; TSSK1; TSSK1B
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Gene Symbols: TSSK1B
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Molecular weight:
41,618 Da
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Basal Isoelectric point:
7.6
Predict pI for various phosphorylation states
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