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CCL6
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23. Belongs to the intercrine beta (chemokine CC) family. High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of mouse Ortholog: 11 C|11 50.85 cM |
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Cellular Component:
extracellular region; extracellular space
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Molecular Function:
CCR chemokine receptor binding; CCR1 chemokine receptor binding; chemoattractant activity; chemokine activity; cytokine activity
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Biological Process:
cell chemotaxis; cellular response to interleukin-1; cellular response to tumor necrosis factor; cellular response to type II interferon; chemokine-mediated signaling pathway; chemotaxis; eosinophil chemotaxis; G protein-coupled receptor signaling pathway; immune response; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity
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Reference #:
P27784
(UniProtKB)
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Alt. Names/Synonyms: C-C motif chemokine 6; C10; CC chemokine C10; Ccl6; CCL6(22-95); CCL6(23-95); chemokine (C-C motif) ligand 6; MRP; MRP-1; OTTMUSP00000000945; Protein C10; Scy; Scya6; small inducible cytokine A6; Small-inducible cytokine A6
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Gene Symbols: Ccl6
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Molecular weight:
12,984 Da
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Basal Isoelectric point:
9.5
Predict pI for various phosphorylation states
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