ITGA4 Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 2 C3|2 47.38 cM
Cellular Component:  cell surface; cell-cell junction; external side of plasma membrane; extracellular exosome; growth cone; integral component of membrane; integrin alpha4-beta7 complex; integrin complex; membrane; neuronal cell body; plasma membrane
Molecular Function:  antigen binding; cell adhesion molecule binding; fibronectin binding; metal ion binding; protein antigen binding
Biological Process:  axonogenesis involved in innervation; blood vessel remodeling; cell adhesion; cell migration; cell-cell adhesion; cell-cell adhesion in response to extracellular stimulus; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-matrix adhesion involved in ameboidal cell migration; cellular response to amyloid-beta; chorio-allantoic fusion; clathrin-dependent extracellular exosome endocytosis; diapedesis; face development; heart development; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; heterotypic cell-cell adhesion; import into cell; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; leukocyte tethering or rolling; mesenchyme development; negative regulation of protein homodimerization activity; neuron projection extension; positive regulation of endothelial cell apoptotic process; positive regulation of leukocyte cell-cell adhesion; positive regulation of leukocyte migration; positive regulation of leukocyte tethering or rolling; positive regulation of T cell migration; positive regulation of vascular endothelial cell proliferation; receptor clustering; substrate adhesion-dependent cell spreading; T cell migration; visceral serous pericardium development
Reference #:  Q00651 (UniProtKB)
Alt. Names/Synonyms: CD49 antigen-like family member D; CD49D; integrin alpha 4; Integrin alpha-4; Integrin alpha-IV; ITA4; Itga4; LPAM subunit alpha; Lymphocyte Peyer patch adhesion molecules subunit alpha; OTTMUSP00000014305; VLA-4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Symbols: Itga4
Molecular weight: 115,696 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene