ITGA4 Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. Belongs to the integrin alpha chain family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of human Ortholog: 2q31.3
Cellular Component:  cell surface; external side of plasma membrane; growth cone; integrin alpha4-beta1 complex; integrin alpha4-beta7 complex; integrin complex; neuronal cell body; plasma membrane
Molecular Function:  C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; fibronectin binding; integrin binding; metal ion binding; protein antigen binding; protein binding
Biological Process:  axonogenesis involved in innervation; B cell differentiation; cell adhesion mediated by integrin; cell-cell adhesion; cell-cell adhesion in response to extracellular stimulus; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-matrix adhesion involved in ameboidal cell migration; cellular response to amyloid-beta; cellular response to cytokine stimulus; clathrin-dependent extracellular exosome endocytosis; diapedesis; endodermal cell differentiation; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; leukocyte tethering or rolling; negative regulation of protein homodimerization activity; neuron projection extension; positive regulation of endothelial cell apoptotic process; positive regulation of leukocyte tethering or rolling; positive regulation of T cell migration; positive regulation of vascular endothelial cell proliferation; receptor clustering; substrate adhesion-dependent cell spreading
Reference #:  P13612 (UniProtKB)
Alt. Names/Synonyms: 269C wild type; alpha 4 subunit of VLA-4 receptor; antigen CD49D, alpha-4 subunit of VLA-4 receptor; CD49 antigen-like family member D; CD49D; IA4; integrin alpha 4; Integrin alpha-4; integrin alpha-4 subunit; Integrin alpha-IV; integrin subunit alpha 4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); ITA4; ITGA4; MGC90518; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha
Gene Symbols: ITGA4
Molecular weight: 114,900 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein