COL3A1 Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Belongs to the fibrillar collagen family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 1 C1.1|1 23.67 cM
Cellular Component:  collagen trimer; collagen type III trimer; collagen-containing extracellular matrix; extracellular matrix; extracellular region; extracellular space
Molecular Function:  extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; integrin binding; metal ion binding; platelet-derived growth factor binding; protease binding; SMAD binding
Biological Process:  aorta smooth muscle tissue morphogenesis; blood vessel development; cell-matrix adhesion; cellular response to amino acid stimulus; cerebral cortex development; collagen fibril organization; digestive tract development; extracellular matrix organization; heart development; integrin-mediated signaling pathway; negative regulation of immune response; negative regulation of neuron migration; peptide cross-linking; positive regulation of Rho protein signal transduction; response to cytokine; response to radiation; skin development; supramolecular fiber organization; transforming growth factor beta receptor signaling pathway; wound healing
Reference #:  P08121 (UniProtKB)
Alt. Names/Synonyms: AW550625; CO3A1; Col3; Col3a-1; Col3a1; Collagen alpha-1(III) chain; collagen, type III, alpha 1; KIAA4231; minisatellite 10w detected by probe MMS10; mKIAA4231; MMS10-W; Ms10w; OTTMUSP00000023637; procollagen, type III, alpha 1; Tsk; Tsk-; Tsk-2; Tsk2
Gene Symbols: Col3a1
Molecular weight: 138,943 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
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COL3A1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene