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COL3A1
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Belongs to the fibrillar collagen family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 2q32.2 |
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Cellular Component:
collagen type III trimer; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular region; extracellular space
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Molecular Function:
extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; integrin binding; metal ion binding; platelet-derived growth factor binding; protease binding; protein binding; SMAD binding
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Biological Process:
aorta smooth muscle tissue morphogenesis; basement membrane organization; cell-matrix adhesion; cellular response to amino acid stimulus; cerebral cortex development; chondrocyte differentiation; collagen fibril organization; digestive tract development; elastic fiber assembly; endochondral bone morphogenesis; extracellular matrix organization; fibroblast proliferation; heart development; in utero embryonic development; integrin-mediated signaling pathway; layer formation in cerebral cortex; limb joint morphogenesis; lung development; multicellular organism growth; negative regulation of immune response; negative regulation of neuron migration; neuron migration; peptide cross-linking; platelet activation; positive regulation of Rho protein signal transduction; response to angiotensin; response to cytokine; response to radiation; skin development; supramolecular fiber organization; tissue homeostasis; transforming growth factor beta receptor signaling pathway; transforming growth factor beta1 production; wound healing
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Disease: Ehlers-danlos Syndrome, Type Iv, Autosomal Dominant; Polymicrogyria With Or Without Vascular-type Ehlers-danlos Syndrome
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Reference #:
P02461
(UniProtKB)
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Alt. Names/Synonyms: alpha-1 type III collagen; alpha1 (III) collagen; CO3A1; COL3A1; Collagen alpha-1(III) chain; Collagen III; Collagen Type III; collagen type III alpha 1 chain; collagen, fetal; collagen, type III, alpha 1; EDS4A; EDSVASC; Ehlers-Danlos syndrome type IV, autosomal dominant; FLJ34534; PMGEDSV; Type III Collagen
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Gene Symbols: COL3A1
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Molecular weight:
138,564 Da
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Basal Isoelectric point:
6.21
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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