CO3A1 Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. Belongs to the fibrillar collagen family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component:  collagen type III trimer; collagen-containing extracellular matrix; endoplasmic reticulum lumen; extracellular region; extracellular space
Molecular Function:  extracellular matrix structural constituent; extracellular matrix structural constituent conferring tensile strength; integrin binding; metal ion binding; platelet-derived growth factor binding; protease binding; protein binding; SMAD binding
Biological Process:  aorta smooth muscle tissue morphogenesis; cell-matrix adhesion; cellular response to amino acid stimulus; cerebral cortex development; collagen fibril organization; digestive tract development; extracellular matrix organization; heart development; integrin-mediated signaling pathway; negative regulation of immune response; negative regulation of neuron migration; peptide cross-linking; platelet activation; positive regulation of Rho protein signal transduction; regulation of immune response; response to cytokine; response to mechanical stimulus; response to radiation; skeletal system development; skin development; supramolecular fiber organization; transforming growth factor beta receptor signaling pathway; wound healing
Disease: Ehlers-danlos Syndrome, Type Iv, Autosomal Dominant; Polymicrogyria With Or Without Vascular-type Ehlers-danlos Syndrome
Reference #:  P02461 (UniProtKB)
Alt. Names/Synonyms: alpha-1 type III collagen; alpha1 (III) collagen; CO3A1; COL3A1; Collagen alpha-1(III) chain; collagen type III alpha 1 chain; collagen, fetal; collagen, type III, alpha 1; EDS4A; EDSVASC; Ehlers-Danlos syndrome type IV, autosomal dominant; FLJ34534; PMGEDSV
Gene Symbols: COL3A1
Molecular weight: 138,564 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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