SOX10 Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Expressed in fetal brain and in adult brain, heart, small intestine and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 15 E1|15 37.7 cM
Cellular Component:  chromatin; cytoplasm; membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; identical protein binding; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription factor binding
Biological Process:  cell differentiation; cell maturation; central nervous system myelination; developmental growth; digestive tract morphogenesis; enteric nervous system development; in utero embryonic development; lacrimal gland development; melanocyte differentiation; morphogenesis of a branching epithelium; morphogenesis of an epithelium; negative regulation of apoptotic process; negative regulation of canonical Wnt signaling pathway; negative regulation of DNA-templated transcription; negative regulation of Schwann cell proliferation; negative regulation of transcription by RNA polymerase II; neural crest cell migration; neuroblast proliferation; oligodendrocyte development; oligodendrocyte differentiation; peripheral nervous system development; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of gliogenesis; positive regulation of myelination; positive regulation of neuroblast proliferation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation by RNA polymerase II promoter
Reference #:  Q04888 (UniProtKB)
Alt. Names/Synonyms: Dom; dominant megacolon; Protein SOX-21; Sox; Sox-10; Sox10; Sox21; SRY (sex determining region Y)-box 10; SRY-box containing gene 10; Transcription factor SOX-10; Transcription factor SOX-M
Gene Symbols: Sox10
Molecular weight: 49,949 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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SOX10

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein