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SOX6
Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. Expressed in a wide variety of tissues, most abundantly in skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of mouse Ortholog: 7 F1|7 61.29 cM |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription cis-regulatory region binding
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Biological Process:
astrocyte differentiation; brain development; cardiac muscle cell differentiation; cartilage condensation; cartilage development; cell differentiation; cell fate commitment; cell morphogenesis; cellular response to transforming growth factor beta stimulus; central nervous system development; chondrocyte differentiation; erythrocyte development; erythrocyte differentiation; gene expression; hemopoiesis; in utero embryonic development; multicellular organism development; negative regulation of cardiac muscle cell differentiation; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; oligodendrocyte cell fate specification; oligodendrocyte differentiation; positive regulation of cartilage development; positive regulation of chondrocyte differentiation; positive regulation of DNA-templated transcription; positive regulation of mesenchymal stem cell differentiation; positive regulation of transcription by RNA polymerase II; post-embryonic development; regulation of DNA-binding transcription factor activity; regulation of DNA-templated transcription; regulation of gene expression; regulation of transcription by RNA polymerase II; spinal cord oligodendrocyte cell differentiation
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Reference #:
P40645
(UniProtKB)
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Alt. Names/Synonyms: AI987981; Sox-6; SOX-LZ; Sox6; SRY (sex determining region Y)-box 6; SRY-box containing gene 6; Transcription factor SOX-6
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Gene Symbols: Sox6
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Molecular weight:
91,803 Da
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Basal Isoelectric point:
7.65
Predict pI for various phosphorylation states
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