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RARG
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor |
| Chromosomal Location of mouse Ortholog: 15 F3|15 57.4 cM |
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Cellular Component:
chromatin; cytoplasm; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription factor activity; metal ion binding; nuclear receptor activity; nuclear retinoid X receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
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Biological Process:
anterior/posterior pattern specification; apoptotic process; bone development; bone morphogenesis; cell differentiation; cell population proliferation; cellular response to leukemia inhibitory factor; chondrocyte development; embryonic camera-type eye development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; epithelium development; face development; gland development; glandular epithelial cell development; growth plate cartilage chondrocyte growth; growth plate cartilage development; Harderian gland development; hormone-mediated signaling pathway; limb development; multicellular organism growth; negative regulation of cartilage development; negative regulation of cell differentiation; negative regulation of chondrocyte differentiation; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; neural tube closure; positive regulation of apoptotic process; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; programmed cell death; prostate gland epithelium morphogenesis; regulation of DNA-templated transcription; regulation of gene expression; regulation of myelination; regulation of myeloid cell differentiation; reproductive structure development; response to retinoic acid; retinoic acid receptor signaling pathway; stem cell proliferation; trachea cartilage development
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Reference #:
P18911
(UniProtKB)
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Alt. Names/Synonyms: AI385767; MGC11555; MGC18523; Nr1b3; Nuclear receptor subfamily 1 group B member 3; RAR gamma 2; RAR-gamma; RARD; Rarg; RARgamma2; Retinoic acid receptor gamma; retinoic acid receptor gamma 4; retinoic acid receptor, gamma
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Gene Symbols: Rarg
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Molecular weight:
50,891 Da
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Basal Isoelectric point:
7.83
Predict pI for various phosphorylation states
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CST Pathways:
Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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