CALCR This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Isoform 2: Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase. Does not undergo receptor internalization following ligand binding. Belongs to the G-protein coupled receptor 2 family. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 6 A1|6 1.81 cM
Cellular Component:  acrosomal vesicle; amylin receptor complex 1; amylin receptor complex 2; amylin receptor complex 3; axon; cilium; integral component of membrane; membrane; neuron projection; neuronal cell body; plasma membrane
Molecular Function:  amylin receptor activity; calcitonin binding; calcitonin gene-related peptide receptor activity; calcitonin receptor activity; G protein-coupled receptor activity; transmembrane signaling receptor activity
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; amylin receptor signaling pathway; cell surface receptor signaling pathway; cross-receptor inhibition within G protein-coupled receptor heterodimer; G protein-coupled receptor signaling pathway; negative regulation of ossification; osteoclast differentiation; positive regulation of adenylate cyclase activity; positive regulation of calcium ion import across plasma membrane; positive regulation of cell death; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase A signaling; positive regulation of protein kinase B signaling; regulation of mRNA stability; response to amyloid-beta; response to glucocorticoid; signal transduction
Reference #:  Q60755 (UniProtKB)
Alt. Names/Synonyms: Calcitonin receptor; Calcr; Clr; CT-R
Gene Symbols: Calcr
Molecular weight: 62,469 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene