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MIRab13
Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth. Note: This description may include information from UniProtKB.
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| Chromosomal Location of Human Ortholog: 15 E1|15 37.7 cM |
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Cellular Component:
cell; endosome; endosome membrane; extrinsic component of membrane; late endosome; membrane
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Molecular Function:
identical protein binding; metal ion binding; phosphatidic acid binding; protein binding; Rab GTPase binding
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Biological Process:
cellular response to nerve growth factor stimulus; endocytic recycling; endocytosis; neuron projection development; plasma membrane tubulation; protein localization to endosome; protein targeting to membrane; protein transport; receptor-mediated endocytosis; retrograde transport, endosome to plasma membrane; slow endocytic recycling
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Reference #:
Q8BGT6
(UniProtKB)
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Alt. Names/Synonyms: 260; AI448246; D15Mit26; D15Mit260; D15N2; D15N2e; EST573322; EST820961; Kiaa1668; MICAL-like protein 1; Micall1; microtubule associated monooxygenase, calponin and LIM domain containing -like 1; microtubule associated monoxygenase, calponin and LIM domain containing -like 1; MILK1; MIRab13; mKIAA1668; Molecule interacting with Rab13
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Gene Symbols: Micall1
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Molecular weight:
94,079 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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