RASGRP1 Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Belongs to the RASGRP family. Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 15q14
Cellular Component:  cytosol; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; mast cell granule; membrane; plasma membrane
Molecular Function:  calcium ion binding; diacylglycerol binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; lipid binding; phosphatidylcholine binding; phosphatidylserine binding; protein homodimerization activity; Ras guanyl-nucleotide exchange factor activity; zinc ion binding
Biological Process:  activation of GTPase activity; cell differentiation; cytokine production; inflammatory response to antigenic stimulus; MAPK cascade; mast cell degranulation; positive regulation of ERK1 and ERK2 cascade; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of GTPase activity; positive regulation of interferon-gamma secretion; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of protein phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of T cell differentiation in thymus; positive regulation of tumor necrosis factor production; protein complex oligomerization; Ras protein signal transduction; regulation of ERK1 and ERK2 cascade; regulation of phosphatidylinositol 3-kinase signaling; secretory granule localization; signal transduction; vesicle transport along microtubule
Disease: Immunodeficiency 64
Reference #:  O95267 (UniProtKB)
Alt. Names/Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor II; CALDAG-GEFI; CalDAG-GEFII; GRP1; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; hRasGRP1; MGC129998; MGC129999; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Ras guanyl-releasing protein; RAS guanyl-releasing protein 1; RASGRP; RASGRP1; V
Gene Symbols: RASGRP1
Molecular weight: 90,402 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein