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RASGRP1
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types. Belongs to the RASGRP family. Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level). Expressed in NK cells (at protein level) (PubMed:19933860). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Ras |
| Chromosomal Location of human Ortholog: 15q14 |
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Cellular Component:
cytosol; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; membrane; plasma membrane
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Molecular Function:
calcium ion binding; diacylglycerol binding; guanyl-nucleotide exchange factor activity; identical protein binding; lipid binding; phosphatidylcholine binding; zinc ion binding
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Biological Process:
activation of GTPase activity; B cell activation; B cell proliferation; cell differentiation; inflammatory response to antigenic stimulus; mast cell degranulation; natural killer cell activation; positive regulation of ERK1 and ERK2 cascade; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of protein phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of T cell differentiation in thymus; positive regulation of tumor necrosis factor production; positive regulation of type II interferon production; Ras protein signal transduction; regulation of ERK1 and ERK2 cascade; regulation of p38MAPK cascade; regulation of phosphatidylinositol 3-kinase signaling; regulation of phospholipase C activity; secretory granule localization; signal transduction; T cell activation; T cell proliferation; vesicle transport along microtubule
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Disease: Immunodeficiency 64
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Reference #:
O95267
(UniProtKB)
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Alt. Names/Synonyms: Calcium and DAG-regulated guanine nucleotide exchange factor II; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor II; CALDAG-GEFI; CalDAG-GEFII; GRP1; guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A; hRasGRP1; IMD64; MGC129998; MGC129999; ras activator RasGRP; RAS guanyl nucleotide-releasing protein 1; RAS guanyl releasing protein 1; RAS guanyl releasing protein 1 (calcium and DAG-regulated); Ras guanyl-releasing protein; RAS guanyl-releasing protein 1; RASGRP; RASGRP1; V
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Gene Symbols: RASGRP1
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Molecular weight:
90,402 Da
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Basal Isoelectric point:
8.2
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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GPCR Signaling to MAPKs
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