|
DYNLT1
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. Belongs to the dynein light chain Tctex-type family. Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level). Note: This description may include information from UniProtKB.
|
| Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of mouse Ortholog: 17 A1|17 3.97 cM |
|
Cellular Component:
axonal growth cone; cytoplasm; cytoplasmic dynein complex; cytoplasmic microtubule; dynein complex; Golgi apparatus; growth cone; lamellipodium; neuronal cell body; photoreceptor inner segment; secretory vesicle
|
|
Molecular Function:
dynein intermediate chain binding; G-protein beta-subunit binding; GTP-dependent protein binding; identical protein binding; protein binding; transmembrane transporter binding
|
|
Biological Process:
axon development; cardiac muscle cell apoptotic process; dendrite development; establishment of mitotic spindle orientation; intracellular transport of viral protein in host cell; microtubule-based movement; negative regulation of ERK1 and ERK2 cascade; negative regulation of mitochondrial membrane permeability; negative regulation of neurogenesis; neuron projection morphogenesis; positive regulation of neuron projection development; positive regulation of Rac protein signal transduction; regulation of cytoskeleton organization; regulation of G protein-coupled receptor signaling pathway; regulation of GTPase activity
|
|
Reference #:
P51807
(UniProtKB)
|
|
Alt. Names/Synonyms: Activator of G-protein signaling 2; AGS2; DYLT1; Dynein light chain Tctex-type 1; dynein light chain Tctex-type 1B; dynein light chain Tctex-type 1D; Dynl; Dynlt1; Dynlt1b; MGC107110; MGC107111; t-complex testis expressed 1; T-complex testis-specific protein 1; Tctel1; TCTEX-1; Tctex1
|
|
Gene Symbols: Dynlt1
|
|
Molecular weight:
12,483 Da
|
|
Basal Isoelectric point:
5
Predict pI for various phosphorylation states
|
