TAB1 May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15|15 E1
Cellular Component:  cytosol; nuclear speck; nucleus; protein-containing complex
Molecular Function:  catalytic activity; kinase activator activity; magnesium-dependent protein serine/threonine phosphatase activity; mitogen-activated protein kinase p38 binding; protein binding; protein kinase activator activity; protein serine/threonine phosphatase activity; protein-containing complex binding
Biological Process:  activation of MAPKKK activity; aorta development; cardiac septum development; coronary vasculature development; heart morphogenesis; in utero embryonic development; lung development; positive regulation of MAP kinase activity; protein dephosphorylation; transforming growth factor beta receptor signaling pathway
Reference #:  Q8CF89 (UniProtKB)
Alt. Names/Synonyms: 2310012M03Rik; b2b449C; b2b449Clo; beta activated kinase-1 binding protein-1; Map3k; Map3k7ip1; mitogen activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; Tab1; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1
Gene Symbols: Tab1
Molecular weight: 54,616 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene