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TAB1
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Activator; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 15|15 E1 |
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Cellular Component:
cytosol; nuclear speck; protein-containing complex
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Molecular Function:
kinase activator activity; mitogen-activated protein kinase p38 binding; protein binding; protein serine/threonine phosphatase activity; protein-containing complex binding
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Biological Process:
aorta development; cardiac septum development; coronary vasculature development; heart morphogenesis; in utero embryonic development; lung development; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; transforming growth factor beta receptor signaling pathway
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Reference #:
Q8CF89
(UniProtKB)
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Alt. Names/Synonyms: 2310012M03Rik; b2b449C; b2b449Clo; beta activated kinase-1 binding protein-1; Map3k; Map3k7ip1; mitogen activated protein kinase kinase kinase 7 interacting protein 1; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; Tab1; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1
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Gene Symbols: Tab1
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Molecular weight:
54,616 Da
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Basal Isoelectric point:
5.31
Predict pI for various phosphorylation states
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CST Pathways:
Inhibition of Apoptosis
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NF-kB Signaling
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Regulation of P38 MAPKs
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Toll-Like Receptor Signaling
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Wnt/ß-Catenin Signaling
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