TAB1 May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Activator; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component:  cytosol; endosome membrane; nuclear speck; protein-containing complex
Molecular Function:  enzyme activator activity; protein binding; protein-containing complex binding
Biological Process:  activation of MAPK activity; activation of MAPKKK activity; aorta development; cardiac septum development; coronary vasculature development; Fc-epsilon receptor signaling pathway; heart morphogenesis; I-kappaB kinase/NF-kappaB signaling; in utero embryonic development; interleukin-1-mediated signaling pathway; JNK cascade; lung development; MyD88-dependent toll-like receptor signaling pathway; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of NF-kappaB transcription factor activity; protein dephosphorylation; protein deubiquitination; stimulatory C-type lectin receptor signaling pathway; transforming growth factor beta receptor signaling pathway
Reference #:  Q15750 (UniProtKB)
Alt. Names/Synonyms: 3'-Tab1; MAP3K7IP1; MGC57664; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB1; TAK1-binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Gene Symbols: TAB1
Molecular weight: 54,644 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TAB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein