TAB1
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Activator; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 22q13.1 |
Cellular Component:
cytosol; endosome membrane; nuclear speck; protein-containing complex
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Molecular Function:
enzyme activator activity; kinase activator activity; mitogen-activated protein kinase p38 binding; protein binding; protein serine/threonine phosphatase activity; protein-containing complex binding
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Biological Process:
aorta development; cardiac septum development; coronary vasculature development; heart morphogenesis; in utero embryonic development; lung development; positive regulation of MAP kinase activity; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; transforming growth factor beta receptor signaling pathway
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Reference #:
Q15750
(UniProtKB)
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Alt. Names/Synonyms: 3'-Tab1; MAP3K7IP1; MGC57664; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB1; TAK1-binding protein 1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
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Gene Symbols: TAB1
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Molecular weight:
54,644 Da
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Basal Isoelectric point:
5.31
Predict pI for various phosphorylation states
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CST Pathways:
Inhibition of Apoptosis
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NF-kB Signaling
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Regulation of P38 MAPKs
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Toll-Like Receptor Signaling
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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