TAB1 May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 22q13.1
Cellular Component:  cytosol; endosome membrane; nuclear speck; protein-containing complex
Molecular Function:  enzyme activator activity; kinase activator activity; mitogen-activated protein kinase p38 binding; protein binding; protein serine/threonine phosphatase activity; protein-containing complex binding
Biological Process:  aorta development; cardiac septum development; coronary vasculature development; heart morphogenesis; in utero embryonic development; lung development; positive regulation of MAP kinase activity; positive regulation of protein serine/threonine kinase activity; protein dephosphorylation; transforming growth factor beta receptor signaling pathway
Reference #:  Q15750 (UniProtKB)
Alt. Names/Synonyms: 3'-Tab1; MAP3K7IP1; MGC57664; mitogen-activated protein kinase kinase kinase 7 interacting protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TAB1; TAK1-binding protein 1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1; TGF-beta activated kinase 1/MAP3K7 binding protein 1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; TGF-beta-activated kinase 1-binding protein 1; transforming growth factor beta-activated kinase-binding protein 1
Gene Symbols: TAB1
Molecular weight: 54,644 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  Toll-Like Receptor Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TAB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein