GPIX The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component:  integral component of plasma membrane; plasma membrane
Molecular Function:  protein binding
Biological Process:  blood coagulation; blood coagulation, intrinsic pathway; cell adhesion; platelet activation
Disease: Bernard-soulier Syndrome
Reference #:  P14770 (UniProtKB)
Alt. Names/Synonyms: CD42a; Glycoprotein 9; glycoprotein IX (platelet); GP-IX; GP9; GPIX; Platelet glycoprotein IX
Gene Symbols: GP9
Molecular weight: 19,046 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
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GPIX

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene