CRIK
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: AGC group; CRIK subfamily; DMPK family; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
Chromosomal Location of human Ortholog: 12q24.23 |
Cellular Component:
cytosol
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Molecular Function:
ATP binding; metal ion binding; PDZ domain binding; protein binding; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein serine/threonine kinase inhibitor activity; scaffold protein binding; SH3 domain binding; transcription coactivator binding
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Biological Process:
generation of neurons; mitotic cell cycle; mitotic cytokinesis; negative regulation of hippo signaling; neuron apoptotic process; positive regulation of cytokinesis; protein phosphorylation
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Disease: Microcephaly 17, Primary, Autosomal Recessive
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Reference #:
O14578
(UniProtKB)
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Alt. Names/Synonyms: CIT; CITK; citron (rho-interacting, serine/threonine kinase 21); Citron Rho-interacting kinase; citron rho-interacting serine/threonine kinase; CRIK; CTRO; KIAA0949; MCPH17; rho-interacting, serine/threonine kinase 21; serine/threonine kinase 21; Serine/threonine-protein kinase 21; STK21
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Gene Symbols: CIT
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Molecular weight:
231,431 Da
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Basal Isoelectric point:
6.16
Predict pI for various phosphorylation states
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