CRIK an AGC kinase that is a RHO/RAC effector. Binds to the GTP-bound forms of RHO and RAC1. Required for postnatal hippocampal neurogenesis. Rho/CRIK suppresses differentiation and is associated with induction of KyoT1/2, a LIM domain protein gene implicated in integrin-mediated processes and Notch signaling. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Overexpressed in mantle-cell lymphoma (MCL), an aggressive type of B-cell lymphoma. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; DMPK family; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component:  cleavage furrow; cytosol; Golgi cisterna; midbody; neuronal cell body; nucleus
Molecular Function:  ATP binding; metal ion binding; PDZ domain binding; protein binding; protein serine/threonine kinase activity; scaffold protein binding; SH3 domain binding
Biological Process:  G2/M transition of mitotic cell cycle; generation of neurons; Golgi organization; intracellular signal transduction; liver development; mitotic cell cycle; mitotic cytokinesis; neuron apoptotic process; positive regulation of cytokinesis; protein phosphorylation; regulation of actin polymerization or depolymerization
Disease: Microcephaly 17, Primary, Autosomal Recessive
Reference #:  O14578 (UniProtKB)
Alt. Names/Synonyms: CIT; citron (rho-interacting, serine/threonine kinase 21); Citron Rho-interacting kinase; CRIK; CTRO; KIAA0949; rho-interacting, serine/threonine kinase 21; Serine/threonine-protein kinase 21; STK21
Gene Symbols: CIT
Molecular weight: 231,431 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein