PCNA Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. Belongs to the PCNA family. Note: This description may include information from UniProtKB.

Protein type: Cell cycle regulation; DNA replication

Chromosomal Location of human Ortholog: 20p12.3

Cellular Component: centrosome; chromatin; cyclin-dependent protein kinase holoenzyme complex; nuclear body; nuclear lamina; nuclear replication fork; nucleoplasm; nucleus; PCNA complex; PCNA-p21 complex; replication fork; replisome

Molecular Function: chromatin binding; damaged DNA binding; dinucleotide insertion or deletion binding; DNA polymerase binding; enzyme binding; estrogen receptor binding; histone acetyltransferase binding; identical protein binding; MutLalpha complex binding; protein binding; purine-specific mismatch base pair DNA N-glycosylase activity; receptor tyrosine kinase binding

Biological Process: base-excision repair, gap-filling; cellular response to hydrogen peroxide; cellular response to UV; cellular response to xenobiotic stimulus; DNA damage response, detection of DNA damage; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epithelial cell differentiation; error-free translesion synthesis; error-prone translesion synthesis; estrous cycle; heart development; liver regeneration; mismatch repair; mitotic telomere maintenance via semi-conservative replication; negative regulation of transcription by RNA polymerase II; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; positive regulation of deoxyribonuclease activity; positive regulation of DNA repair; positive regulation of DNA replication; protein ubiquitination; regulation of transcription involved in G1/S transition of mitotic cell cycle; replication fork processing; response to cadmium ion; response to dexamethasone; response to estradiol; response to L-glutamate; telomere maintenance; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair; translesion synthesis; viral process

Disease: Ataxia-telangiectasia-like Disorder 2

Reference #: P12004 (UniProtKB)

Alt. Names/Synonyms: ATLD2; Cyclin; DNA polymerase delta auxiliary protein; MGC8367; PCNA; Proliferating cell nuclear antigen

Gene Symbols: PCNA

Molecular weight: 28,769 Da

Basal Isoelectric point: 4.57 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PCNA

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