KOR-3 G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. Belongs to the G-protein coupled receptor 1 family. Detected in blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 2 H4|2 103.74 cM
Cellular Component:  cytoplasmic vesicle; membrane; neuron projection; plasma membrane
Molecular Function:  G protein-coupled opioid receptor activity; G protein-coupled receptor activity; neuropeptide binding; nociceptin receptor activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; behavior; conditioned place preference; eating behavior; G protein-coupled opioid receptor signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of blood pressure; negative regulation of cAMP-mediated signaling; negative regulation of voltage-gated calcium channel activity; neuropeptide signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of urine volume; regulation of locomotor rhythm; sensory perception of pain; signal transduction
Reference #:  P35377 (UniProtKB)
Alt. Names/Synonyms: K3 opiate receptor; Kappa-type 3 opioid receptor; KOR-3; KOR3; LC13; LC132; MOR; MOR-C; morc; N/OFQ receptor; Nociceptin receptor; nociceptin/ orphaninFQ receptor; NOP; Oor; opioid receptor-like 1; Oprl; Oprl1; OPRX; ORGC; ORL1; Orphanin FQ receptor; OTTMUSP00000018249; OTTMUSP00000018252; OTTMUSP00000018253; XOR1
Gene Symbols: Oprl1
Molecular weight: 40,491 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene