SCN8A Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.6/SCN8A subfamily. Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15 56.39 cM|15 F1
Cellular Component:  axon; axon initial segment; dendrite; glutamatergic synapse; integral component of membrane; integral component of postsynaptic density membrane; integral component of presynaptic active zone membrane; membrane; neuronal cell body; node of Ranvier; parallel fiber to Purkinje cell synapse; plasma membrane; sodium channel complex; voltage-gated sodium channel complex; Z disc
Molecular Function:  ATP binding; ion channel activity; nucleotide binding; protein binding; sodium channel activity; sodium ion binding; voltage-gated ion channel activity; voltage-gated sodium channel activity
Biological Process:  adult locomotory behavior; adult walking behavior; ion transport; locomotory behavior; membrane depolarization during action potential; muscle organ development; neuromuscular process; neuronal action potential; regulation of ion transmembrane transport; response to toxic substance; sensory perception of sound; sodium ion transmembrane transport; sodium ion transport; transmembrane transport
Reference #:  Q9WTU3 (UniProtKB)
Alt. Names/Synonyms: AI853486; ataxia 3; C630029C19Rik; dmu; med; mnd-2; mnd2; NaCh6; Nav1.6; Nbna1; nmf2; nmf335; nmf58; nur14; Scn8a; seal; Sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; sodium channel, voltage-gated, type VIII, alpha; Voltage-gated sodium channel subunit alpha Nav1.6; voltage-gated sodium channel type VIII alpha protein
Gene Symbols: Scn8a
Molecular weight: 225,141 Da
Basal Isoelectric point: 5.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SCN8A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene