CDX2 Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA. Belongs to the Caudal homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 5 G3|5 86.86 cM
Cellular Component:  condensed nuclear chromosome; nucleoplasm; nucleus; protein-containing complex; transcription repressor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; methyl-CpG binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
Biological Process:  animal organ morphogenesis; anterior/posterior axis specification; anterior/posterior pattern specification; blastocyst development; blood vessel development; cell differentiation; embryo development; endosome to lysosome transport; establishment or maintenance of epithelial cell apical/basal polarity; intestinal epithelial cell differentiation; labyrinthine layer development; multicellular organism development; negative regulation of transcription by RNA polymerase II; pattern specification process; placenta development; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of somitogenesis; regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; stem cell differentiation; trophectodermal cell differentiation
Reference #:  P43241 (UniProtKB)
Alt. Names/Synonyms: caudal type homeo box 2; caudal type homeobox 2; Caudal-type homeobox protein 2; Cdx-2; Cdx2; Homeobox protein CDX-2
Gene Symbols: Cdx2
Molecular weight: 33,476 Da
Basal Isoelectric point: 9.67  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDX2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene