PFKFB1 Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. Liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: Xq13
Cellular Component:  6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex; cytosol
Molecular Function:  6-phosphofructo-2-kinase activity; ATP binding; fructose-2,6-bisphosphate 2-phosphatase activity; fructose-6-phosphate binding; identical protein binding; kinase binding
Biological Process:  animal organ regeneration; carbohydrate phosphorylation; dephosphorylation; fructose 2,6-bisphosphate metabolic process; fructose metabolic process; positive regulation of glucokinase activity; response to cAMP; response to glucagon; response to glucocorticoid; response to insulin; response to starvation
Reference #:  P07953 (UniProtKB)
Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme; Fructose-2,6-bisphosphatase; PFK/FBPase 1; Pfkfb01; Pfkfb1; PFRX
Gene Symbols: Pfkfb1
Molecular weight: 54,763 Da
Basal Isoelectric point: 6.31  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below

PFKFB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene