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NTCP
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. (Microbial infection) Acts as a receptor for hepatitis B virus. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter |
| Chromosomal Location of rat Ortholog: 6q24 |
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Cellular Component:
basolateral plasma membrane; membrane
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Molecular Function:
bile acid transmembrane transporter activity; bile acid:sodium symporter activity
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Biological Process:
bile acid and bile salt transport; bile acid signaling pathway; cellular response to xenobiotic stimulus; regulation of bile acid secretion; response to estrogen; response to ethanol; response to nutrient levels; response to organic cyclic compound; sodium ion transport; transmembrane transport
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Reference #:
P26435
(UniProtKB)
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Alt. Names/Synonyms: Hepatic sodium/bile acid cotransporter; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; NA-dependent cholate transporting protein; Ntcp; Ntcp1; SBACT; Slc10a1; sodium-dependent bile acid cotransporter; sodium-dependent taurocholate cotransporting polypeptide; Sodium/bile acid cotransporter; Sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family), member 1; Solute carrier family 10 member 1; solute carrier family 10, member 1
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Gene Symbols: Slc10a1
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Molecular weight:
39,295 Da
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Basal Isoelectric point:
9.12
Predict pI for various phosphorylation states
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