GATA6 Transcriptional activator. Regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium. May regulate genes that protect epithelial cells from bacterial infection. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Expressed in heart, gut and gut-derived tissues. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 18 A1|18 5.63 cM
Cellular Component:  nuclear membrane; nucleus; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enhancer sequence-specific DNA binding; metal ion binding; protein binding; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  animal organ formation; cardiac muscle cell differentiation; cardiac muscle hypertrophy in response to stress; cardiac muscle tissue development; cardiac vascular smooth muscle cell differentiation; cellular response to BMP stimulus; cellular response to gonadotropin stimulus; cellular response to hypoxia; Clara cell differentiation; endodermal cell differentiation; endodermal cell fate determination; epithelial cell differentiation; in utero embryonic development; intestinal epithelial cell differentiation; liver development; lung saccule development; negative regulation of apoptotic process; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta1 production; negative regulation of transforming growth factor beta2 production; outflow tract septum morphogenesis; pancreas development; pancreatic A cell differentiation; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac muscle myoblast proliferation; positive regulation of cardioblast differentiation; positive regulation of cell cycle arrest; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of gene expression; regulation of transcription, DNA-templated; response to drug; response to estrogen; response to growth factor; smooth muscle cell differentiation; transcription by RNA polymerase II; tube morphogenesis; type B pancreatic cell differentiation; type II pneumocyte differentiation
Reference #:  Q61169 (UniProtKB)
Alt. Names/Synonyms: AA410133; GATA binding protein 6; GATA-6; GATA-binding factor 6; GATA-binding protein 6; Gata6; Transcription factor GATA-6
Gene Symbols: Gata6
Molecular weight: 59,307 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene