GATA6 Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 18 A1|18 5.63 cM
Cellular Component:  nuclear membrane; nucleus; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enhancer sequence-specific DNA binding; metal ion binding; protein binding; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  animal organ formation; cardiac muscle cell differentiation; cardiac muscle hypertrophy in response to stress; cardiac muscle tissue development; cardiac vascular smooth muscle cell differentiation; cellular response to BMP stimulus; cellular response to gonadotropin stimulus; cellular response to hypoxia; Clara cell differentiation; endodermal cell differentiation; endodermal cell fate determination; epithelial cell differentiation; in utero embryonic development; intestinal epithelial cell differentiation; liver development; lung saccule development; negative regulation of apoptotic process; negative regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta1 production; negative regulation of transforming growth factor beta2 production; outflow tract septum morphogenesis; pancreas development; pancreatic A cell differentiation; phospholipid metabolic process; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell apoptotic process; positive regulation of cardiac muscle cell proliferation; positive regulation of cardiac muscle myoblast proliferation; positive regulation of cardioblast differentiation; positive regulation of cell cycle arrest; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of gene expression; regulation of transcription, DNA-templated; response to drug; response to estrogen; response to growth factor; smooth muscle cell differentiation; transcription by RNA polymerase II; tube morphogenesis; type B pancreatic cell differentiation; type II pneumocyte differentiation
Reference #:  Q61169 (UniProtKB)
Alt. Names/Synonyms: AA410133; GATA binding protein 6; GATA-6; GATA-binding factor 6; GATA-binding protein 6; Gata6; Transcription factor GATA-6
Gene Symbols: Gata6
Molecular weight: 59,307 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene