ZA20D2 Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. Highly expressed in skeletal muscle. Expressed in fetal cochlea. Also expressed in infant brain, fetal heart, pancreatic islet, melanocyte, pineal gland, placenta, corneal stroma, and parathyroid tumor. Weakly expressed or undetectable in adult brain, heart, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. Expressed in rhabdomyosarcoma RD cells (at protein level). Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 9q21.13
Cellular Component:  cytoplasm
Molecular Function:  DNA binding; protein binding; zinc ion binding
Reference #:  O76080 (UniProtKB)
Alt. Names/Synonyms: AN1-type zinc finger protein 5; ZA20D2; ZFAN5; ZFAND5; ZFAND5A; Zinc finger A20 domain-containing protein 2; zinc finger AN1-type containing 5; Zinc finger protein 216; zinc finger, A20 domain containing 2; zinc finger, AN1-type domain 5; ZNF216
Gene Symbols: ZFAND5
Molecular weight: 23,132 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
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ZA20D2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein