ATP8A1 Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Acts as aminophospholipid translocase at the plasma membrane in neuronal cells. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.3.1; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 5|5 C3.1
Cellular Component:  cytoplasmic vesicle; endoplasmic reticulum; Golgi apparatus; integral component of membrane; integral component of synaptic vesicle membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; trans-Golgi network
Molecular Function:  ATP binding; magnesium ion binding; metal ion binding; nucleotide binding; phospholipid-translocating ATPase activity; protein binding
Biological Process:  learning; lipid transport; phospholipid translocation; phospholipid transport; positive regulation of cell migration; positive regulation of phospholipid translocation
Reference #:  P70704 (UniProtKB)
Alt. Names/Synonyms: AI481521; AI853962; APLT; AT8A1; Atp; Atp3a2; Atp8a1; ATPase 8A1, aminophospholipid transporter (APLT), class I; ATPase 8A1, p type; ATPase class I type 8A member 1; ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1; Atpc1; AW743152; AW822227; B230107D19Rik; Chromaffin granule ATPase II; ClassI; KIAA4233; mKIAA4233; OTTMUSP00000025685; OTTMUSP00000025712; P4-ATPase flippase complex alpha subunit ATP8A1; Phospholipid-transporting ATPase IA; Probable phospholipid-transporting ATPase IA
Gene Symbols: Atp8a1
Molecular weight: 131,413 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
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ATP8A1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene